New strategy for sepsis: Targeting a key role of platelet-neutrophil interaction

نویسندگان

  • Xu Wang
  • Weiting Qin
  • Bingwei Sun
چکیده

Neutrophil and platelet are essential arms of the innate immune response. In sepsis, platelet abnormal activation as well as neutrophil paralysis are well recognized. For platelet, it is characterized by the contribution to disseminated intravascular coagulation (DIC) and the enhanced inflammation response. In terms of neutrophil, its dysfunction is manifested by the impaired recruitment and migration to the infectious foci, abnormal sequestration in the remote organs, and the delayed clearance. More recently, it has been apparent that together platelet-neutrophil interaction can induce a faster and harder response during sepsis. This article focuses on the activation of platelet, dysfunction of neutrophil, and the interaction between them during sepsis and profiles some of the molecular mechanisms and outcomes in these cellular dialogues, providing a novel strategy for treatment of sepsis.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Eosinopenia and Neutrophil to lymphocyte ratio as diagnostic tools in neonatal early onset sepsis -a single center observational study

Background and Objective: Neonatal sepsis is associated with high mortality and has a favourable outcome when recognized and treated in a timely manner. In resource-limited settings, there is a need for an affordable test with a short turnaround time for timely diagnosis of sepsis. The aim of this study was to find out the role of eosinopenia and neutrophil-to-lymphocyte ratio (NLR) in screenin...

متن کامل

Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation.

Acute lung injury (ALI) causes high mortality, but its molecular mechanisms are poorly understood. Acid aspiration is a frequent cause of ALI, leading to neutrophil sequestration, increased permeability, and deterioration of gas exchange. We investigated the role of platelet-neutrophil interactions in a murine model of acid-induced ALI. Acid aspiration induced P-selectin-dependent platelet-neut...

متن کامل

The Prognostic Role of Mean Platelet Volume (MPV) in Sever Sepsis: is it True?

Background: The purpose of the present study was to examine the role of mean platelet volume (MPV) in comparison with Sequential Organ Failure Assessment (SOFA), quick SOFA (qSOFA), and Mortality in Severe Sepsis in the Emergency Department (MISSED) scoring systems in predicting hospital mortality among patients with severe sepsis. Methods: This follow-up stud...

متن کامل

TREM-1 ligand expression on platelets enhances neutrophil activation.

The triggering receptor expressed on myeloid cells 1 (TREM-1) plays an important role in the innate immune response related to severe infections and sepsis. Modulation of TREM-1-associated activation improves the outcome in rodent models for pneumonia and sepsis. However, the identity and occurrence of the natural TREM-1 ligands are so far unknown, impairing the further understanding of the bio...

متن کامل

Flow Cytometric Determination of Neutrophil CD64 (nCD64) in Children with Community Acquired Pneumonia

Background The expression of CD64 in neutrophils (nCD64) has shown utility in the diagnosis of sepsis. The aim of this study was to evaluate the diagnostic value of neutrophil CD64 in pneumonia as an early marker for infection and correlate its level with the outcome of...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 2  شماره 

صفحات  -

تاریخ انتشار 2014